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The activities of both CK-MB and AST were significantly ( P 0.05) elevated in 5-FU group as compared to Control group

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Unlike endogenous -MSH, which degrades within seconds via enzymatic cleavage, MT-1's modified structure resists degradation by serum proteases, allowing sustained melanocortin receptor activation across multiple tissue types

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Moreover, conventional targeted therapeutic agents, such as monoclonal antibodies and smallmolecule inhibitors, encounter notable challenges in tissue penetration